期刊
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
卷 23, 期 6, 页码 1457-1464出版社
SPRINGER
DOI: 10.1007/s10856-012-4621-7
关键词
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资金
- Slovak Scientific Agency VEGA [2/0157/09, 2/0040/10]
- Research and Development Operational Programme
- ERDF
- Slovak Research and Development Agency [APVV-0032-06, APVV-SK-PL-0029-09]
Poly(2-oxazolines) represent promising polymer materials for biomedical applications. The activation of mouse lymphoid macrophage line P388.D1 (clone 3124) by two selected representatives of poly(2-oxazolines), namely poly(2-ethyl-2-oxazoline) (PETOX100) and poly[2-(4-aminophenyl)-2-oxazoline-co-2-ethyl-2-oxazoline] (AEOX10), was assessed in vitro. The immunomodulatory efficacy of both polymers was evaluated via the induced release of pro-inflammatory cytokines (TNF-alpha, IL-1 alpha and IL-6) and the acceleration of reactive free radicals. The present study revealed effective structure-immunomodulating associations of AEOX10 and PETOX100, which are desirable in biomedical and pharmaceutical applications of aliphatic and aromatic poly (2-oxazolines) .
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