期刊
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
卷 23, 期 2, 页码 555-563出版社
SPRINGER
DOI: 10.1007/s10856-011-4518-x
关键词
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资金
- Academy of Sciences of the Czech Republic [AV0Z50390703, AV0Z50390512]
- Ministry of Education, Youth and Sports of the Czech Republic [NPV II 2B06130, 1M0510, ME10145]
- Grant Agency of the Academy of Sciences [IAA500390702]
- Czech Science Foundation [GA202/09/1151]
- IGA MZCR [NT12156]
- Grant Agency of the Charles University [122508]
The structural properties of microfiber meshes made from poly(2-hydroxyethyl methacrylate) (PHEMA) were found to significantly depend on the chemical composition and subsequent cross-linking and nebulization processes. PHEMA microfibres showed promise as scaffolds for chondrocyte seeding and proliferation. Moreover, the peak liposome adhesion to PHEMA microfiber scaffolds observed in our study resulted in the development of a simple drug anchoring system. Attached foetal bovine serum-loaded liposomes significantly improved both chondrocyte adhesion and proliferation. In conclusion, fibrous scaffolds from PHEMA are promising materials for tissue engineering and, in combination with liposomes, can serve as a simple drug delivery tool.
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