期刊
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
卷 20, 期 11, 页码 2285-2294出版社
SPRINGER
DOI: 10.1007/s10856-009-3805-2
关键词
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资金
- National science foundation [30570503]
- National high technology research and developed program [2008AA03Z305]
- Shanghai municipality [08520704600, 0852 nm03400]
The aim of this study is to investigate an innovative tissue engineering scaffold with a controllable drug-releasing capability. The hypothesis is that the nanofibers fabricated by coaxial electrospinning could encapsulate and release sustainedly Tetracycline Hydrochloride (TCH). To testify the hypothesis, nanofibers were prepared by coaxial electrospinning from Poly(l-lactid-co-epsilon-caprolactone) [PLLACL]/2,2,2-Frifluoroethanol (TFE) solutions (as the shell solutions) and TCH/TFE solutions (as the core solutions). In addition, nanofibers of PLLACL-blend-TCH were also prepared as the control by mix electrospinning. The relationship between fibers morphologies and processed conditions in electrospinning were investigated. TCH release behaviors from the nanofibrous mats were studied. The antibacterial properties of aforementioned nanofibers were detected by the Escherichia coli growth-inhibiting tests. The results indicated that the nanofibers prepared by coaxial-electrospinning had the desired and controllable TCH encapsulation/release profile; thus, it could be utilized as both a drug encapsulation/release vehicle and a tissue engineering scaffold.
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