期刊
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
卷 21, 期 2, 页码 551-556出版社
SPRINGER
DOI: 10.1007/s10856-009-3925-8
关键词
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资金
- National 973 Basic Research Program of China [20108529902]
- National 863 Research Program of China [2007AA021203]
- National Natural Science Foundation of China [50673058]
- Shanghai Municipal Public Health Bureau [2008Y088]
- Science and Technology Commission of Shanghai Municipality [0852nm05800]
This study aims to determine the sensitivity, specificity and accuracy of epidermal growth factor receptor monoclonal antibody (EGFRmAb) modified poly(lactic acid-co-l-lysine) nanoparticles (PLA-PLL-EGFRmAb) NPs delivery system to EGFR positive cancer cells. In the study, a new PLA-PLL-EGFRmAb NPs was prepared. The cellular cytotoxicity, cellular uptake, and the targeted effect for hepatocellular carcinoma of PLA-PLL-EGFRmAb NPs were investigated. In vitro, the findings of Flow cytometry and Confocal Laser scanning Biological Microscopy showed that PLA-PLL-EGFRmAb NPs can bind to hepatocellular carcinoma cells and were uptaken effectively. In vivo in the SMMC-7721 xenograft mouse model, PLA-PLL-EGFRmAb NPs could target to the tumor effectively, which demonstrated a better targeting. These results showed that the PLA-PLL-EGFRmAb NPs have the potential to be used as a target delivery carrier for tumor therapies.
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