期刊
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
卷 19, 期 4, 页码 1459-1466出版社
SPRINGER
DOI: 10.1007/s10856-008-3375-8
关键词
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The design, development and evaluation of biomaterials that can sustain life or restore a certain body function, is a very important and rapidly expanding field in materials science. A key issue in the development of biomaterials is the design of a material that mimics the natural environment of cells. In the present work, we have therefore developed hydrogel materials that contain both a protein (gelatin) and a glycosaminoglycan (chondroitin sulphate) component. To enable a permanent crosslinking, gelatin and chondroitin sulphate were first chemically modified using methacrylic anhydride. Hydrogels containing modified gelatin (gel-MOD) and/or chondroitin sulphate (CS-MOD) were cryogenically treated as optimised earlier for gel-MOD based hydrogels (Van Vlierberghe et al., Biomacromolecules 8:331-337, 2007). The cryogenic treatment leads to tubular pores for gel-MOD based systems. For CS-MOD based hydrogels and hydrogels containing both gel-MOD and CS-MOD, a curtain-like architecture (i.e. parallel plates) was observed, depending on the applied CS-MOD concentration. In our opinion, this is the first paper in which such well-defined scaffold architectures have been obtained without using rapid prototyping techniques.
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