期刊
PATHOLOGY INTERNATIONAL
卷 65, 期 11, 页码 595-602出版社
WILEY
DOI: 10.1111/pin.12350
关键词
immunohistochemistry; lung cancer; SWI; SNF complex
类别
资金
- JSPS KAKENHI [25860275, 25460432, 26293080]
- Grants for Research on Human Genome Tailor from the Ministry of Health, Labor, and Welfare of Japan
- Smoking Research Foundation
- Foundation for the Development of the Community
- Grants-in-Aid for Scientific Research [25460432, 25860275, 26293080, 25670178] Funding Source: KAKEN
The switch/sucrose non-fermenting (SWI/SNF) complex has recently emerged as a novel tumor suppressor in various human cancers. In the present study, we analyzed the expression of multiple SWI/SNF subunits in primary non-small cell lung cancer (NSCLC). A total of 133 NSCLC, consisting of 25 squamous cell carcinomas (SCC), 70 adenocarcinomas (AD), 16 large cell carcinomas (LC), and 22 pleomorphic carcinomas (PL), were immunohistochemically examined for the expression of BRG1, BRM, BAF47, ARID1A, and ARID1B. The frequency at which reductions in the expression of BRG1 were observed was significantly higher in the LC-PL group (13/38, 34.2%) than in the SCC-AD group (7/95, 7.4%). Similarly, the frequency at which reductions in the expression of BRM were observed was significantly higher in the LC-PL group (17/38, 44.7%) than in the SCC-AD group (14/95, 14.7%). The loss of the expression of ARID1A, ARID1B, and BAF47 was observed only in a fraction of NSCLC cases. Furthermore, the frequency at which the concurrent loss of multiple subunits of the SWI/SNF complex was observed was significantly higher in the LC-PL group (10/38, 26.3%) than in the SCC-AD group (8/95, 8.4%). Collectively, these results indicate that the loss of the SWI/SNF complex was related to dedifferentiation in NSCLC.
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