期刊
JOURNAL OF MATERIALS RESEARCH
卷 23, 期 12, 页码 3161-3168出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1557/JMR.2008.0384
关键词
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资金
- National Institutes of Health [ROI GM 076479]
- NIH Southeast Regional Center of Excellence for Biodefense [5 U54 AI57157]
An antigenic mimic of the Ebola glycoprotein was synthesized and tested for its ability to be recognized by ail anti-Ebola glycoprotein antibody. Epitope-mapping procedures yielded a suitable epitope that, when presented oil the surface of I nanoparticle, forms a Structure that Is recognized by an antibody specific for the native protein. This mimic-antibody interaction has been quantitated through ELISA and QCM-based methods and yielded all affinity (K-d = 12 x 10(-6) M) within two orders of magnitude of the reported affinity of the native Ebola glycoprotein for the same antibody. These results suggest that the rational design approach described herein is a Suitable method for the further development of protein-based antigenic mimics with potential applications in vaccine development and sensor technology.
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