期刊
PATHOBIOLOGY
卷 82, 期 6, 页码 264-268出版社
KARGER
DOI: 10.1159/000440866
关键词
Breast; Amyloidosis; Crest syndrome; Transthyretin
资金
- Generalitat de Catalunya Suport Grups de Recerca AGAUR [2014-SGR-795]
- Red Tematica de Investigacion Cooperativa en Cancer (RTICC) [RD12/0036/0036]
- Xarxa de Bancs de Tumors de Catalunya (XBTC)
Background: Amyloidosis involving the breast is a rare finding and it may present as a solitary mass called 'amyloid tumor'. According to the largest case series, the amyloid deposits are usually of the AL type (commonly kappa light chain). Methods: We report 3 cases diagnosed at our institution in the period from 2000 to 2015. Radiological, histological and immunohistochemical studies were performed. Results and Conclusions: Together with a case presenting in a patient with multiple myeloma, we describe 2 unique presentations including 1 associated with CREST syndrome in a patient with a previous history of breast carcinoma and another, also associated with cancer, with transthyretin deposits in a woman with a TTR gene mutation and a family history of familial amyloidotic polyneuropathy. These cases are an example of the vast heterogeneity of this disorder regarding its clinical presentation, the type of amyloid deposits and other diseases associated with breast amyloidosis. (C) 2015 S. Karger AG, Basel
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