期刊
JOURNAL OF MATERIALS CHEMISTRY
卷 22, 期 37, 页码 19412-19417出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2jm31618h
关键词
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资金
- National Eye Institute of the National Institutes of Health (NIH)
- Partnership for Innovation Program of the National Science Foundation
A simple one-step approach to electrospin Type I collagen in the presence of the chemical crosslinking agents 1-ethyl-3-(3-dimethyl-aminopropyl)-1-carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS) has been developed to generate water-insoluble collagen nanofiber scaffolds without the need for post-crosslinking. SEM images indicate that fibrous surface morphology of collagen scaffolds was well retained after the in situ crosslinking process and following water treatment. The resultant collagen demonstrated a similar uniaxial tensile behavior of native tissue in mechanical testing.
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