期刊
JOURNAL OF MATERIALS CHEMISTRY
卷 22, 期 22, 页码 11173-11178出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2jm30501a
关键词
-
资金
- Australian Research Council (ARC) [LP0882681, DP1095861, DP1094070, DP0987969]
Herein, we report a core-shell pH-responsive drug-carrier based on chitosan-coated mesoporous silica nanospheres. The efficient positively charged polymer (chitosan) coating is realized by the phosphoramidate covalent bonding between phosphonate groups on the surface of the mesoporous silica nanoparticles (MSNs) and amino groups on chitosan. A pH-responsive release of ibuprofen has been achieved by varying the shell structure of positively charged chitosan in the designed pH 4.0-7.4 solution. Under basic conditions, chitosan forms a gel like structure which is insoluble and hence prevents ibuprofen release at pH 7.4. When the pH is below its PI (6.3), the drug has been released due to protonation of the amino group on chitosan. These results imply that the chitosan coated-MSNs are promising platforms to construct pH-responsive controlled drug delivery systems.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据