Bifunctional catechol based linkers for modification of TiO2 surfaces

Bifunctional linkers for modification of TiO2 nanoparticles were prepared containing a catechol group for TiO2 surface attachment and a maleimide and alkyne group for Michael addition and Cu catalysed Huisgen cycloaddition respectively. Peptide and fluorophore functionalised TiO2 NPs were prepared, different purification methodologies were explored and conjugates were characterized using a range of methods.