期刊
JOURNAL OF MATERIALS CHEMISTRY
卷 22, 期 18, 页码 9041-9045出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2jm30325f
关键词
-
资金
- World Premier International Research Center Initiative (WPI), MEXT, Japan
- [20226015]
- [21241023]
- Grants-in-Aid for Scientific Research [20226015, 21241023, 22108503, 24108703] Funding Source: KAKEN
In our study, water dispersible magnetite (Fe3O4) nanoparticles were continuously synthesized in water under high temperature and pressure in the presence of 3,4-dihydroxyhydrocinnamic acid (DHCA) by using a tubular flow reactor. The prepared Fe3O4 nanoparticles were well dispersed in water because the surfaces of the nanoparticles were fully covered by DHCA molecules and the -COOH groups in the DHCA molecules were exposed to the surrounding water. Cytokines such as IL-12 and TNF-alpha were not produced from the dendritic cells of mice by co-incubation with our synthesized Fe3O4. This indicates that the synthesized Fe3O4 had no immune stimulating property for the dendritic cells of the mouse. Therefore, our synthesized Fe3O4 nanoparticles are suitable for biological applications such as magnetic resonance imaging contrast agents and carriers for drug and gene delivery, and in areas such as hyperthermia therapy for cancer, biosensors, and tissue engineering.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据