期刊
JOURNAL OF MATERIALS CHEMISTRY
卷 22, 期 18, 页码 9293-9300出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2jm30692a
关键词
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资金
- TUBITAK [109T573]
- EBILTEM (Ege University, Research and Application Center of Science and Technology) [2010BIL004]
- Istanbul Technical University
Herein, we demonstrate the synthesis and application of water-soluble, biomolecule conjugated PPP copolymers bearing poly(ethylene glycol) (PEG) side chains as fluorescent probes for the in vitro imaging of cancer cells. The targeting of fluorescent polymers to breast cancer cells allows effective visualization and discrimination of MCF7 cells from human mammary epithelial cells. Furthermore, these materials are also suitable for efficient radiolabeling via I-125 which enables dual-modality holding the possibility of both radioactive and fluorescence imaging in cancer diagnosis applications.
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