期刊
JOURNAL OF MATERIALS CHEMISTRY
卷 22, 期 11, 页码 5128-5136出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2jm15586a
关键词
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资金
- National 973 Basic Research Program of China [2010CB529902]
- Science and Technology Commission of Shanghai Municipality [2010CB529902, 1052nm05900]
- Nature Science Foundation of Shanghai [11ZR1417300]
- National Natural Science Foundation of China [81101738]
Calcium phosphate/glycerylphosphorylcholine (GPC)-mPEG hybrid porous nanospheres (CaP/GPC-mPEG NSs) were prepared by a facile room-temperature method and employed as carriers to deliver mitoxantrone (MIT) as well as to overcome multidrug resistance (MDR). The successful synthesis of CaP/GPC-mPEG NSs was determined by FTIR and H-1-NMR. The MIT encapsulating efficiency of the NSs was 89.5 wt% with a loading content of 6.0 wt%. The release of MIT at neutral pH was fast, with close to 76% of its total drug content being released within the first 24 h. The as-prepared CaP/GPC-mPEG NSs were quite safe as confirmed by MTT assays. The cytotoxicities and cellular uptake of drug-loaded CaP/GPC-mPEG NSs were tested against human breast cancer (MCF-7) cells and their multidrug resistant (MCF-7/MIT) cells. Compared to free MIT, the MIT-loaded CaP/GPC-mPEG NSs exhibited high cytotoxicities in MCF-7 and MCF-7/MIT cells. The results suggest that CaP/GPC-mPEG NSs greatly enhanced the cellular uptake efficiency, and this was supported by confocal laser scanning microscopy. Additionally, both CaP and GPC-mPEG are biocompatible and biodegradable thus the as-prepared CaP/GPC-mPEG hybrid porous nanospheres are promising for drug delivery and overcoming MDR.
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