期刊
JOURNAL OF MATERIALS CHEMISTRY
卷 22, 期 24, 页码 12329-12338出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2jm31891a
关键词
-
资金
- Shanghai Education Commission [11CXY16, 11ZZ31]
- Shanghai Science and Technology Commission [10PJ1409900]
- National Natural Science Foundation of China [21074095, 21174107]
- Fok Ying Tong Education Foundation [132018]
- Fundamental Research Funds for the Central Universities [0500219141]
- Universities of Ministry of Education [NCET-10-0627]
- PhD Program Foundation of Ministry of Education [20110072110048]
- SRF for ROCS
- SEM
- Shanghai Institutions of Higher Learning
Presented in this article is the synthesis of a new class of block copolymer, poly(ethylene oxide)-block-poly(tert-butyl acrylate-stat-acrylic acid) [PEO-b-P(AA-stat-tBA)], which can self-assemble into polymer vesicles with tuneable sizes at various conditions. The biocompatible and hydrophilic PEO chains form the vesicle coronas, while the PAA-stat-PtBA chains form the membrane. Superparamagnetic iron oxide nanoparticles (SPIONs) were generated in situ within the membrane of the polymer vesicles by nanoprecipitation. H-1 NMR, GPC, DLS, TGA, VSM and TEM were employed to characterize the structure and properties of the block copolymer, polymer vesicles and Fe3O4-decorated magnetic polymer vesicles. The water-dispersible, biocompatible, drug deliverable and superparamagnetic polymer vesicles exhibited excellent colloidal stability at a range of pH conditions and very high T-2 relaxivity, demonstrating ultra-sensitivity for magnetic resonance imaging and promising potential applications in nanomedicine.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据