期刊
JOURNAL OF MATERIALS CHEMISTRY
卷 22, 期 30, 页码 15362-15369出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2jm32720a
关键词
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资金
- National Natural Science Foundation of China [50903007, 21144002, 21071012]
- Fok Ying Tung Education Foundation [121048]
- Program for New Century Excellent Talents in University [NCET-10-0203]
- National High Technology Development Program of China (863 Program) [2011AA030102]
- Natural Science Foundation of Jiangsu Province of China [BK2011781]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Base of Production, Education & Research of Prospective Joint Research Project of Jiangsu Province [BY2011109]
The ability to manipulate and control the surface properties of layered double hydroxide (LDH) nanoparticles is of crucial importance in the designing of LDH-based carriers of therapeutic agents. In this work, surface-initiated atom transfer radical polymerization (ATRP) of zwitterionic 3-dimethyl(methacryloyloxyethyl) ammonium propane sulfonate (DMAPS) is first employed to tailor the functionality of LDH surfaces in a well-controlled manner and produce a series of well-defined hemocompatible hybrids (termed as LDHPS). The blood compatibilities of the modified LDH nanoparticles were investigated using coagulation tests, complement activation, platelet activation, hemolysis assay, morphological changes of red blood cells, and cytotoxicity assay. The results confirmed that the P(DMAPS) grafting can substantially enhance the hemocompatibility of the LDH particles, and the LDHPS hybrids can be used as biomaterials without causing any hemolysis. With the versatility of surface-initiated ATRP and the excellent hemocompatibility of zwitterionic polymer chains, the LDH nanoparticles with desirable blood properties can be readily tailored to cater to various biomedical applications.
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