期刊
JOURNAL OF MATERIALS CHEMISTRY
卷 22, 期 45, 页码 23952-23962出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2jm34862d
关键词
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资金
- NSERC
- Manitoba Health Research Council
- Manitoba Institute of Child Health
- National Basic Research Program of China [2012CB619100]
- China 863 Project [2012AA020504]
This paper reports a functionalized cationic poly(amidoamine) crosslinker synthesized by Michael addition of peptide mimetic agmatine to N,N'-bis(acryloyl)cystamine. A polyethylene glycol diacrylate (PEGDA) hybrid hydrogel was developed using a functionalized crosslinker with cell adhesion capability and tunable stiffness. This engineered hydrogel presents a 3-D in-growth of cells and the cryosection shows remarkable morphology of the gel. The tunable stiffness of this hydrogel can regulate the osteogenic differentiation of mesenchymal stem cells from RT-PCR. Both in vitro and in vivo tests demonstrate adjustable degradation rate and biocompatibility. The crosslinker and its hydrogels hold promising potential for tissue engineering applications.
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