期刊
JOURNAL OF MATERIALS CHEMISTRY
卷 21, 期 10, 页码 3448-3454出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0jm02494e
关键词
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资金
- Educational Committee Foundation of Tianjin City [20090102]
- NSFC [50933003]
- National Key Scientific Program of China [2011CB964902]
- MoST [2009AA032304[863], 2008AA02Z129[863]]
- NSF of Tianjin City of China [08JCZDJC25300]
A dual-targeting drug delivery and pH-sensitive controlled release system based on multi-functionalized graphene oxide (GO) was established in order to enhance the effect of targeted drug delivery and realize intelligently controlled release. A superparamagnetic GO-Fe3O4 nanohybrid was firstly prepared via a simple and effective chemical precipitation method. Then folic acid, a targeting agent toward some tumor cells, was conjugated onto Fe3O4 nanoparticles via the chemical linkage with amino groups of the 3-aminopropyl triethoxysilane (APS) modified superparamagnetic GO-Fe3O4 nanohybrid, to give the multi-functionalized GO. Doxorubicin hydrochloride (Dox) as an anti-tumor drug model was loaded onto the surface of this multi-functionalized GO via pi-pi stacking. The drug loading capacity of this multi-functionalized GO is as high as 0.387 mg mg(-1) and the drug release depends strongly on pH values. Cell uptake studies were carried out using fluorescein isothiocyanate labeled or Dox loaded multi-functionalized GO to evaluate their targeted delivery property and toxicity to tumor cells. The results show that this multi-functionalized GO has potential applications for targeted delivery and the controlled release of anticancer drugs.
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