期刊
JOURNAL OF MATERIALS CHEMISTRY
卷 21, 期 30, 页码 11244-11252出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1jm10329f
关键词
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资金
- NSFC [21021061, 20925103, 20871100]
- Fok Ying Tung Education Foundation [121011]
- NSF of Fujian Province [2009J06005]
- Fundamental Research Funds for the Central Universities [2010121015]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
A synthetic method to prepare novel multifunctional core-shell-structured mesoporous silica nanoparticles for simultaneous magnetic resonance (MR) and fluorescence imaging, cell targeting and photosensitization treatment has been developed. Superparamagnetic magnetite nanoparticles and fluorescent dyes are co-encapsulated inside nonporous silica nanoparticles as the core to provide dual-imaging capabilities (MR and optical). The photosensitizer molecules, tetra-substituted carboxyl aluminum phthalocyanine (AlC4Pc), are covalently linked to the mesoporous silica shell and exhibit excellent photo-oxidation efficiency. The surface modification of the core-shell silica nanoparticles with folic acid enhances the delivery of photosensitizers to the targeting cancer cells that overexpress the folate receptor, and thereby decreases their toxicity to the surrounding normal tissues. These unique advantages make the prepared multifunctional core-shell silica nanoparticles promising for cancer diagnosis and therapy.
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