期刊
JOURNAL OF MATERIALS CHEMISTRY
卷 21, 期 40, 页码 15950-15956出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1jm12570b
关键词
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资金
- National Natural Science Foundation of China [51033005, 20874093, 50973102]
- Ministry of Science and Technology of China [2010CB934000]
Stimuli-responsive biocompatible nanocarriers are very promising for controlled drug release. Here, we report redox-and temperature-responsive biocompatible nanocapsules prepared by growing a temperature-responsive biocompatible shell from 3-(trimethoxysilyl) propyl methacrylate-modified silica nanoparticles (SiO2-MPS) via precipitation polymerization, cross-linking the shell with bioreducible chemical linkages, and subsequently removing the silica core by hydrofluoric acid etching. The produced nanocapsules are redox-and temperature-responsive. TEM, FT-IR, TGA, and XPS were used to characterize the nanocapsules. Dynamic light scattering (DLS) was performed to demonstrate the bioreducible and temperature-responsive properties of the nanocapsules. The lower critical solution temperature (LCST) of the nanocapsules can be tuned precisely. Fluorescein isothiocyanate (FITC) was encapsulated into the nanocapsules and used as a model drug molecule to demonstrate the controlled release behavior under external stimuli.
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