期刊
JOURNAL OF MATERIALS CHEMISTRY
卷 21, 期 33, 页码 12473-12478出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1jm10764j
关键词
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资金
- Ministry of Health & Welfare, Republic of Korea [A090728]
We fabricated dextran-coated magnetic nanoclusters (Dex-MNCs) for targeted magnetic resonance (MR) imaging of inflammatory macrophages. Dex-MNCs were prepared through encapsulation of hydrophobic magnetic nanocrystals (MNCs) by pyrenyl dextran in order that MNCs could achieve increased colloidal stability in aqueous phase as well as strongly interact with macrophages. Dex-MNCs exhibited biocompatibility and sufficient targeting efficiency against macrophages with strengthened MR contrast effect from in vitro/in vivo studies. Considering these results, we confirmed that Dex-MNCs could accurately detect inflammatory macrophage via MR imaging.
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