Effect of physico-chemical parameters on the toxicity of inorganic nanoparticles

In this highlight, attempts have been made to focus on the effect of physico-chemical properties of nanoparticles, such as chemical composition, solubility, particle size, and specific surface area, on the toxicity. Among various inorganic particles, layered double hydroxides on nano scales were especially studied in terms of the toxicity in cell culture systems and in animal models as well. Important major issues and challenges in toxicity evaluation of nanomaterials are also described to answer key questions about their toxicity potential. Understanding the interrelationship between the physico-chemical properties and toxicity of nanoparticles will provide new insights into development of novel materials for biological and medical applications with minimized side effects.