期刊
JOURNAL OF MATERIALS CHEMISTRY
卷 21, 期 42, 页码 16717-16734出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1jm11558h
关键词
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资金
- DFG [BI 1337/6-1, Forschergruppe FOR-1145, INST 271/249-1, INST 271/247-1, INST 271/248-1]
Both function and use of nanoparticles (NPs) to a great extent are dominated by interfacial energies, which in turn can be addressed by chemical modifications. This article focuses exclusively on the use of 'click'-chemistry for NP-surface modification, also putting a major focus on the application of the resulting NPs in bio- and nanoscience. As 'click'-chemistry is a universal method to link reaction partners in high efficiency, solvent insensitivity and at moderate reaction conditions, its use for engineering NP surfaces has become widespread. The basic approach of Cu(I)-catalyzed azide/alkyne 'click' (CuAAC) chemistry for NP-science is elucidated in this article, together with the applications of the resulting surface modified NPs in medicine, nanotechnology and bioassay-science.
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