期刊
JOURNAL OF MATERIALS CHEMISTRY
卷 21, 期 23, 页码 8422-8426出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1jm10272a
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资金
- UChicago Argonne, LLC
- Operator of Argonne National Laboratory (Argonne'')
- Argonne
- U.S. Department of Energy Office of Science Laboratory [DE-AC02-06CH11357]
We report a doxorubicin loaded chitosan biopolymer-ferromagnetic disks hybrid system capable of on-demand magnetomechanically induced release of drug molecules. Gold covered ferromagnetic disks were encapsulated into the polymer scaffold through the assembly of the thiolated chitosan on the disk's gold surface followed by entrapping of the doxorubicin drug within a cross-linked polymer matrix. We demonstrate that the release process can be effectively tuned and controlled by varying the magnetic field characteristics: orientation, amplitude, frequency and duration.
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