4.5 Article

Quantitative and fiber-selective evaluation of pain and sensory dysfunction in patients with Parkinson's disease

期刊

PARKINSONISM & RELATED DISORDERS
卷 21, 期 4, 页码 361-365

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2015.01.008

关键词

Parkinson's disease; Pain; Thresholds

资金

  1. Priority Academic Program Development of Jiangsu Higher Education Institutions
  2. Jiangsu Provincial Special Program of Medical Science [BL2014042]
  3. Suzhou Science and Technology Development Program [SZS201205]
  4. Suzhou Clinical Key Disease Diagnosis and Treatment Technology Foundation [LCZX201304]

向作者/读者索取更多资源

Introduction: Pain and sensory disturbances affect many patients with Parkinson's disease (PD). The present study aimed to evaluate the pain and sensory sensitivity of each class of afferent fibers in PD patients and determine the effects of dopaminergic therapy on pain and sensory sensitivity. Methods: Current perception threshold (CPT) and pain tolerance thresholds (PTT) at three frequencies, 2000 Hz, 250 Hz, and 5 Hz, to stimulate A beta fibers, A delta fibers, and small C-polymodal fibers, respectively, were measured in 72 PD patients and 35 healthy controls. Results: CPT was higher at all three frequencies and PIT was lower at 2000 Hz and 250 Hz in PD patients with pain versus healthy controls (P < 0.05). CPT was higher at 2000 Hz and 250 Hz and PIT was lower at 2000 Hz and 250 Hz in PD patients without pain versus healthy controls (P < 0.05). PD patients with pain exhibited higher CPT at 5 Hz and 250 Hz than PD patients without pain (P < 0.05). Dopaminergic therapy did not affect CPT or PPT in PD patients (P> 0.05). Conclusions: Abnormal A delta fiber- and A beta fiber-dependent sensory inputs may exist in PD. Abnormal sensory inputs via C fibers and A delta fibers might be associated with the presence of pain in PD. Because dopaminergic therapy failed to mitigate these sensory and pain dysfunctions, mechanisms not involving the dopaminergic pathway are likely to be implicated. (c) 2015 Elsevier Ltd. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据