期刊
PARKINSONISM & RELATED DISORDERS
卷 21, 期 10, 页码 1247-1250出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2015.07.019
关键词
Deep brain stimulation; Parkinson's disease; Long-term effects
资金
- German Academic Exchange Service
- Forschungskommission, Heinrich-Heine-University, Dusseldorf (Germany)
- Helmholtz Society
- Stiftung fur Altersforschung
- DFG
- BMBF
- Volkswagen Foundation
Background: This study was conducted to better understand the development of clinical efficacy and impedance levels in the long-term course of deep brain stimulation (DBS) of the subthalamic nucleus (STN) in Parkinson's disease (PD). Methods: In this retrospective study of twenty PD patients, the motor part of the Unified Parkinson's Disease Rating Scale was periodically assessed i) after withdrawal of medication and inactivated stimulation, ii) after withdrawal of medication with activated stimulation and iii) after challenge with L-Dopa during activated stimulation up to 13 years after surgery. Results: STN-DBS with or without medication significantly improved motor function up to 13 years after surgery. The contribution of axial symptoms increased over time. While the stimulation parameters were kept constant, the therapeutic impedances progressively declined. Conclusion: STN-DBS in PD remains effective in the long-term course of the disease. Constant current stimulation might be preferable over voltage-controlled stimulation, as it would alleviate the impact of impedance changes on the volume of tissue activated. (C) 2015 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据