期刊
JOURNAL OF MATERIALS CHEMISTRY
卷 20, 期 36, 页码 7782-7787出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0jm01059f
关键词
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资金
- National Natural Science Funds of China [50772062]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry (36th)
- Taishan Scholar Foundation [ts20070713]
- Research Award Fund for Outstanding Middle-Aged and Young Scientist of Shandong Province, China [BS2009CL025/032]
Various nanoparticles are used to fabricate innovative systems for drug encapsulation and cancer therapy. In this paper, the hierarchical core-shell nanostructures composed of gold nanoparticles and poly(dimethylsiloxane)-poly(ethylene glycol) (PDMS-PEG) block copolymers are fabricated via a hydrosilylation reaction. The obtained gold/copolymer nanocomposites display a desired amphiphilic property and can be well-dispersed in water when the PEG blocks are long enough. The hydrophobic drug hypocrellin B (HB) can be encapsulated into these water-dispersible nanocomposites based on the hydrophobic-hydrophobic interaction between HB molecules and PDMS segments. The gold/copolymer nanocomposites loaded with HB show a rational anticancer ability in the photodynamic therapy although the gold/copolymer nanocomposites without drug also have a little cytotoxicity. Such hierarchically structured core-shell nanocomposites can be considered as water-dispersible nanotanks for hydrophobic drugs in the development of multifunctional biodelivery systems.
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