期刊
JOURNAL OF MATERIALS CHEMISTRY
卷 19, 期 9, 页码 1252-1257出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b816636f
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资金
- National Health Research Institutes of Taiwan [MED-096-PP-04, NM-096-PP-03]
- National Science Council of Taiwan [NSC 96-2221-E-400-002]
Functionalization of mesoporous silica nanoparticles (MSNs) with Pd-porphyrins for cancer cell photodynamic therapy is reported. The composite platform, MSN-PdTPP, expands the role of Pd-porphyrins from their routine use as phosphorescence probes for oxygen sensing/imaging (diagnostics) to that of novel nano-photosensitizers for cancer cell phototherapy (therapeutics). The utility of MSN-PdTPP in the phototherapeutic treatment of MDA-MB-231 breast cancer cells is also evaluated, suggesting it is a promising cancer theranostic platform.
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