期刊
JOURNAL OF MATERIALS CHEMISTRY
卷 19, 期 19, 页码 2902-2905出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b822835c
关键词
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资金
- Korea Healthcare technology R&D Project, Ministry of Health, Welfare & Family Affairs, Republic of Korea [A080661]
We fabricated de novo biocompatible mineral plasmon resonants for localized and systemic treatment of cancer. Biodegradable calcium-phosphate gold nanocomposites were synthesized for inducing a superior surface plasmon resonance effect. The combination of therapeutic antibody, Erbitux (R) and NIR laser with nanocomposites demonstrated the potential for selective bimodal cancer treatment by combination of EGFR-induced signaling inhibition as a systemic treatment and localized photothermal effects caused by the NIR laser.
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