期刊
JOURNAL OF MATERIALS CHEMISTRY
卷 19, 期 32, 页码 5812-5817出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b903845k
关键词
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Tumor-targeting polymeric vesicles were prepared using a mixture of two amphiphilic block copolymers, namely, folate-poly(ethylene glycol)-poly(D,L-lactide) (folate-PEG-PDLLA) and NH2-PEG-PDLLA. The copolymers were synthesized through sequential anionic polymerization in a well-controlled manner. Hydrophilic superparamagnetic iron oxide nanoparticles (SPIONs) were encapsulated in the aqueous core of the polymeric vesicles. Similar to the hydrophilic SPIONs, the SPION-loaded polymeric vesicles exhibited the superparamagnetic property. Moreover, the SPION-loaded polymeric vesicles demonstrated a higher r(2)/r(1) value than a commercially available T-2 agent, Resovist (R), which can be attributed to the high SPION loading level and the SPION clustering effect in the aqueous core of the vesicles. Thus, tumor-targeting, SPION-loaded polymer vesicles can serve as highly efficient T-2 contrast probes for cancer diagnosis and treatment.
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