期刊
JOURNAL OF MATERIALS CHEMISTRY
卷 18, 期 15, 页码 1779-1783出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b717613a
关键词
-
We report a novel approach for synthesizing LuPO4-apoferritin core-shell nanoparticles based on an apoferritin template. To prepare the nanoparticle, we used non-radioactive lutetium as a model target or surrogate for radiolutetium (Lu-177). The central cavity, multi-channel structure, and chemical properties of apoferritin are well-suited for sequentially diffusing lutetium and phosphate ions into the cavity, resulting in a stable core-shell composite. We characterized the synthesized LuPO4-apoferritin nanoparticle using transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS). We found that LuPO4 formed inside the cavity of apoferritin with an 8 nm diameter. We tested the pre-targeting capability of biotin-modified lutetium-apoferritin nanoparticle using streptavidin-modified magnetic beads and streptavidin-modified fluorescein isothiocyanate (FITC) tracer. This paper presents a simple, fast, and efficient method for synthesizing LuPO4-apoferritin nanoparticle for potential applications in radioimmunotherapy and radioimmunoimaging of cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据