期刊
JOURNAL OF MASS SPECTROMETRY
卷 47, 期 2, 页码 242-245出版社
WILEY-BLACKWELL
DOI: 10.1002/jms.2957
关键词
melanin; pheomelanin; GC; MS; MS; triple quadrupole; multiple reaction monitoring mode
资金
- Medical University of Silesia in Katowice, Poland [KNW-2-128/10, KNW-1-032/P/1/0]
Here, we describe the reliable method for the detection and quantitation of a pheomelanin component in melanin pigments. Synthetic melanins with various contents of pheomelanin-type structural units were thermally degraded, and the multiple reaction monitoring mode was applied to detect the pheomelanin markers in the pyrolysates by GC/MS/MS. The method allowed the specific detection and quantitation of a pheomelanin component in melanin with the incorporation of pheomelanin-type units as low as 0.05%. Considering highly universal character of the pheomelanin markers, the method could be applied for structural studies of natural melanin pigments being mixtures of eumelanin and pheomelanin. Copyright (C) 2012 John Wiley & Sons, Ltd.
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