期刊
JOURNAL OF MASS SPECTROMETRY
卷 46, 期 10, 页码 1046-1050出版社
WILEY-BLACKWELL
DOI: 10.1002/jms.1986
关键词
imaging; mass spectrometry; lipids; chemical ink jet printer
资金
- National Institute on Drug Abuse, NIH
Imaging mass spectrometry using matrix-assisted laser desorption/ionization allows the detailed mapping of biomolecules directly from tissue. Matrix deposition is the key step for successful imaging. The appropriate concentration and deposition of matrix is critical for extraction, desorption, and ionization of molecules from tissue without losing molecular localization. The main challenge to meet these criteria is to deposit matrix droplets homogeneously on the tissue section. This work shows how a chemical inkjet printer was used for this purpose resulting in the imaging of phosphatidylcholines and sulfatides. The intricacies involved in effective matrix deposition are discussed. Copyright (C) 2011 John Wiley & Sons, Ltd.
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