期刊
JOURNAL OF MASS SPECTROMETRY
卷 44, 期 7, 页码 1047-1052出版社
WILEY
DOI: 10.1002/jms.1580
关键词
Amadori rearrangement; glycation; ECD; sequencing
资金
- Ministry of Science and Higher Education of Poland [N N401 222734, 3 T09A 029 28]
The electron capture dissociation (ECD) of peptide-derived Amadori products has been successfully applied for their sequencing. In contrast to the collision induced dissociation (CID), based on the vibrational excitation of peptides, the ECD method does not produce ions formed by fragmentation of the hexose moiety, that facilitates interpretation of the obtained spectra. The fragmentation spectrum is dominated by c(n) and z center dot(n) ions, providing the sufficient information for sequencing of peptides and establishing the location of glycated Lys residues in the peptide chain. The ECD experiments were conducted on a series of synthetic peptides and unseparated digests of glycated ubiquitin. Copyright (C) 2009 John Wiley & Sons, Ltd.
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