期刊
JOURNAL OF MASS SPECTROMETRY
卷 43, 期 12, 页码 1673-1678出版社
WILEY
DOI: 10.1002/jms.1456
关键词
amino acid residue; Glu; MS/MS; cyclic lipopeptide; methanol-esterified; McLafferty rearrangement
资金
- National Natural Science Foundation of China [50574040]
- Ministry of Science and Technology of China [2007CB707801]
- Shanghai Municipal Science and Technology Commission [071607014]
The intraresidue rearrangement and loss of the side chain of the Glut residue was found through MS/MS analysis of both original and methanol-esterified lipopeptides. Both Glu and Asp residues in the cyclic lipopeptide were esterified. The MS/MS results showed that the loss of fragment 72 or 86 was induced by McLafferty-type rearrangement from the Glu or esterified Glu. The mechanism of loss of the Glu residue can be used to determine or to corroborate the existence of the Glu and to help understand the fragment formation in MS/MS. The cleavage mechanism and m/z intensities imply that the sodium ion was easier attached and the cleavage would easily occur at specific sites. Copyright (C) 2008 John Wiley & Sons, Ltd.
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