期刊
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
卷 15, 期 2, 页码 225-233出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10911-010-9184-y
关键词
Epithelial-mesenchymal-transition; Pathology; Mouse mammary tumors; Spindle cell phenotype; Heterogeneity; Genetically engineered mice; E-Cadherin; Snail; Invasion; Metastasis
资金
- Congressionally Directed Medical Program, Cancer Research Program Breast Cancer Center of Excellence [BC043200]
- National Cancer Institute's Mouse Models of Human Cancers Consortium [U01 CA105490-01]
- NIH NCRR Mutant Mouse Regional Resource Center [U42 RR14905]
Epithelial-mesenchymal-transition (EMT) tumorigenesis in the mouse was first described over 100 years ago using various terms such as carcinosarcoma and without any comprehension of the underlying mechanisms. Such tumors have been considered artifacts of transplantation and of tissue culture. Recently, EMT tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective leading to the current status in the context of some of the key molecular biology. The biology of mouse mammary EMT tumorigenesis is discussed with comparisons to human breast cancer.
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