期刊
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
卷 364, 期 -, 页码 72-79出版社
ELSEVIER
DOI: 10.1016/j.jmmm.2014.04.001
关键词
Nanoparticle; Superparamagnetic; Magnetite; Sodium oleate; Hyperthermia
资金
- Brazilian research agency CAPES
- Brazilian research agency CNPq
- CNPq Grant [350773, 309676]
We report a simple and low cost methodology to synthesize sodium oleate coated magnetite nano particles for hyperthermia applications. The system consists of oleate coated magnetite nanoparticles with large susceptibility (1065 emu/gT), induced by the dipolar inter particle interaction, with a magnetic core diameter in the 6 nm-12 nm size range. In aqueous medium, the nanoparticles agglomerate to form a monodisperse system, exhibiting a mean hydrodynamic diameter of 60.6 nm +/- 4.1 nm, with a low average polydispersity index of 0.128 +/- 0.003, as required for intravenous applications. The system exhibits promising efficiency for magnetic hyperthermia, with a specific absorption rate of 14 Wig at a low field amplitude of 15.9 kAirn and frequency of 62 kHz. In a 50 mg/mL density in 1 mL, the temperature rises to 42.5 degrees C in 1.9 min. (C) 2014 Elsevier B.V. All rights reserved.
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