期刊
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
卷 321, 期 10, 页码 1356-1363出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmmm.2009.02.038
关键词
Magnetite; Coating; Stabilization; PLA; PLGA; Poly(lactic acid); Poly (lactide-co-glycolide); Magnetic microspheres; Biodegradability
Poly(lactic acid) (PLA)-coated magnetic nanoparticles were made using uncapped PLA with free carboxylate groups. The physical properties of these particles were compared to those of oleate-coated or oleate/sulphonate bilayer (W40) coated magnetic particles. Magnetic microspheres (MMS) with the matrix material poly(lactide-co-glycolide) (PLGA) or PLA were then formed by the emulsion solvent extraction method with encapsulation efficiencies of 40%, 83% and 96% for oleate, PLA and oleate/sulfonate-coated magnetic particles, respectively. MMS made from PLA-coated magnetite were hemocompatible and produced no hemolysis, whereas the other MMS were hemolytic above 0.3mg/mL of blood. (C) 2009 Elsevier B.V. All rights reserved.
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