期刊
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
卷 321, 期 2, 页码 117-122出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmmm.2008.08.055
关键词
Magnetic nanoparticles; Polymer coating; Hyperthermia; Particle size distribution; Dark-field microscopy
资金
- National Science Foundation [NSF DMR-0302544]
Polymer-coated magnetic nanoparticles are hi-tech materials with ample applications in the field of biomedicine for the treatment of cancer and targeted drug delivery. In this study, magnetic nanoparticles were synthesized by chemical reduction of FeCl(2) solution with sodium borohydride and coated with amine-terminated polyethylene glycol (aPEG). By varying the concentration of the reactants, the particle size and the crystallinity of the particles were varied. The particle size was found to increase from 6 to 20 nm and the structure becomes amorphous-like with increase in the molar concentration of the reactant. The magnetization at 1 T field (M(1T)) for all samples is >45 emu/g while the coercivity is in the range of 100-350 Oe. When the ethanol-suspended particles are subjected to an alternating magnetic field of 4 Oe at 500 kHz, the temperature is increased to a maximum normalized temperature (3.8 degrees C/mg) with decreasing particle size. (C) 2008 Elsevier B.V. All rights reserved.
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