期刊
PARASITE IMMUNOLOGY
卷 37, 期 5, 页码 267-273出版社
WILEY
DOI: 10.1111/pim.12150
关键词
ecoimmunology; fitness; Mus; wild
资金
- NERC
- Wellcome Trust
- Leverhulme Trust
- NERC [NE/I022892/1] Funding Source: UKRI
- Natural Environment Research Council [1252388, NE/I022892/1] Funding Source: researchfish
The laboratory mouse, Mus musculus domesticus, has been the workhorse of the very successful laboratory study of mammalian immunology. These studies - discovering how the mammalian immune system can work - have allowed the development of the field of wild immunology that is seeking to understand how the immune responses of wild animals contributes to animals' fitness. Remarkably, there have hardly been any studies of the immunology of wild M.musculus domesticus (or of rats, another common laboratory model), but the general finding is that these wild animals are more immunologically responsive, compared with their laboratory domesticated comparators. This difference probably reflects the comparatively greater previous exposure to antigens of these wild-caught animals. There are now excellent prospects for laboratory mouse immunology to make major advances in the field of wild immunology.
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