期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 49, 期 2, 页码 456-465出版社
WILEY
DOI: 10.1002/jmri.26197
关键词
neuroimaging; magnetic resonance imaging; standardization; morphometry; resting state functional MRI; diffusion tensor imaging
资金
- Alzheimer's Society of Canada [13-32]
- Canadian Institute for Health Research [117121]
- Fonds de recherche du Quebec - Sante / Pfizer Canada - Pfizer-FRQS Innovation Fund [25262]
- Fonds de recherche du Quebec - Sante [30801]
- Fonds de recherche du Quebec - Sante short mission program
- Consortium d'identification precoce de la maladie d'Alzheimer - Quebec through the Fonds de recherche du Quebec - Sante / Pfizer Canada Innovation Fund [25262]
- Canadian Partnership Against Cancer
- Heart and Stroke Foundation of Canada
- Canadian Institutes of Health Research
- Government of Ontario
- Ontario Brain Institute Foundation
- Consortium Quebecois de Decouverte du Medicament
- Alzheimer's Disease Neuroimaging Initiative (ADNI)
BackgroundHarmonized protocols to collect imaging data must be devised, employed, and maintained in multicentric studies to reduce interscanner variability in subsequent analyses. PurposeTo present a standardized protocol for multicentric research on dementia linked to neurodegeneration in aging, harmonized on all three major vendor platforms. The protocol includes a common procedure for qualification, quality control, and quality assurance and feasibility in large-scale studies. Study TypeProspective. SubjectsThe study involved a geometric phantom, a single individual volunteer, and 143 cognitively healthy, mild cognitively impaired, and Alzheimer's disease participants in a large-scale, multicentric study. Field Strength/SequencesMRI was perform with 3T scanners (GE, Philips, Siemens) and included 3D T(1)w, PD/T(2)w, T2*, T(2)w-FLAIR, diffusion, and BOLD resting state acquisitions. AssessmentMeasures included signal- and contrast-to-noise ratios (SNR and CNR, respectively), total brain volumes, and total scan time. Statistical TestsSNR, CNR, and scan time were compared between scanner vendors using analysis of variance (ANOVA) and Tukey tests, while brain volumes were tested using linear mixed models. ResultsGeometric phantom T(1)w SNR was significantly (P<0.001) higher in Philips (mean: 71.4) than Siemens (29.5), while no significant difference was observed between vendors for T(2)w (32.0 and 37.2, respectively, P=0.243). Single individual volunteer T(1)w CNR was higher in subcortical regions for Siemens (P<0.001), while Philips had higher cortical CNR (P= 0.044). No significant difference in brain volumes was observed between vendors (P=0.310/0.582/0.055). The average scan time was 41.0 minutes (SD: 2.8) and was not significantly different between sites (P=0.071) and cognitive groups (P=0.853). Data ConclusionThe harmonized Canadian Dementia Imaging Protocol suits the needs of studies that need to ensure quality MRI data acquisition for the measurement of brain changes across adulthood, due to aging, neurodegeneration, and other etiologies. A detailed description, exam cards, and operators' manual are freely available at the following site: . Level of Evidence: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:456-465.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据