期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 41, 期 4, 页码 909-916出版社
WILEY
DOI: 10.1002/jmri.24639
关键词
aortic coarctation; magnetic resonance imaging; catheterization; pressure drop; computational fluid dynamics
资金
- German Research Foundation [KU1329/10-1]
PurposeTo reduce the need for diagnostic catheterization and optimize treatment in a variety of congenital heart diseases, magnetic resonance imaging (MRI)-based computational fluid dynamics (CFD) is proposed. However, data about the accuracy of CFD in a clinical context are still sparse. To fill this gap, this study compares MRI-based CFD to catheterization in the coarctation of aorta (CoA) setting. Materials and MethodsThirteen patients with CoA were investigated by routine MRI prior to catheterization. 3D whole-heart MRI was used to reconstruct geometries and 4D flow-sensitive phase-contrast MRI was used to acquire flows. Peak systolic flows were simulated using the program FLUENT. ResultsPeak systolic pressure drops in CoA measured by catheterization and CFD correlated significantly for both pre- and posttreatment measurements (pre: r=0.98, p=0.00; post: r=0.87, p=0.00). The pretreatment bias was -0.53.33 mmHg (95% confidence interval -2.55 to 1.47 mmHg). CFD predicted a reduction of the peak systolic pressure drop after treatment that ranged from 17.6 +/- 5.56 mmHg to 6.7 +/- 5.58 mmHg. The posttreatment bias was 3.0 +/- 2.91 mmHg (95% CI -1.74 to 5.43 mmHg). ConclusionPeak systolic pressure drops can be reliably calculated using MRI-based CFD in a clinical setting. Therefore, CFD might be an attractive noninvasive alternative to diagnostic catheterization. J. Magn. Reson. Imaging 2015;41:909-916. (c) 2014 Wiley Periodicals, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据