期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 38, 期 5, 页码 1292-1297出版社
WILEY
DOI: 10.1002/jmri.24045
关键词
skeletal muscle; fat infiltration; DTI; partial volume artifacts; muscle damage assessment; data processing
资金
- NIH/NIAMS [R01 AR050791]
PurposeTo determine the minimum water percentage in a muscle region of interest that would allow diffusion tensor (DT-) MRI data to reflect the diffusion properties of pure muscle accurately. Materials and MethodsProton density-weighted images with and without fat saturation were obtained at the mid-thigh in four subjects. Co-registered DT-MR images were used to calculate the diffusion tensor's eigenvalues and fractional anisotropy. ResultsThe eigenvalues transitioned monotonically as a function of water signal percentage from values near to those expected for pure fat to those for pure muscle. Also, the fractional anisotropy transitioned monotonically from 0.50 (fat) to 0.20 (muscle). For water signal percentages >55%, none of the diffusion indices differed significantly from those for regions of >90% muscle. ConclusionAccounting for the T-1 and T-2 values of muscle and fat and the pulse sequence properties, it is concluded that, as a conservative estimate, regions must contain at least 76% muscle tissue to reflect the diffusion properties of pure muscle accurately. J. Magn. Reson. Imaging 2013;38:1292-1297. (c) 2013 Wiley Periodicals, Inc.
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