期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 40, 期 6, 页码 1342-1346出版社
WILEY
DOI: 10.1002/jmri.24498
关键词
4D flow MRI; aortic valve; unicuspid valve; bicuspid valve; quadricuspid valve; hemodynamics
资金
- NIH NHLBI [R01HL115828]
- DFG (German Research Foundation) [SCHN-1170/2-1]
- SIR Foundation Pilot Research Grant
- American Heart Association Scientist Development [13SDG14360004]
PurposeTo assess the impact of aortic valve morphology on aortic hemodynamics between normal tricuspid and congenitally anomalous aortic valves ranging from unicuspid to quadricuspid morphology. Materials and MethodsAortic three-dimensional (3D) blood flow was evaluated by 4D flow MRI in 14 healthy volunteers with normal trileaflet valves and 14 patients with unicuspid (n=3), bicuspid (n=9, 3 true bicuspid, 3 right-left (RL), 3 right-noncoronary (RN) leaflet fusion, and quadricuspid aortic valves (n=2). Data analysis included the co-registered visualization of aortic valve morphology with systolic 3D blood flow. The influence of valve morphology on aortic hemodynamics was quantified by valve flow angle. ResultsAll RL-bicuspid aortic valve (BAV) were associated with flow jets directed toward the right anterior aortic wall while RN-fusion and unicuspid valves resulted in flow jet patterns toward the right-posterior or posterior wall. Flow angles were clearly influenced by valve morphology (47 degrees 10, 28 degrees +/- 2, 29 degrees +/- 18, 18 degrees +/- 12, 15 degrees +/- 2 for unicuspid, true BAV, RN-BAV, RL-BAV, quadricuspid valves) and increased compared with controls (7.2 degrees +/- 1.1, P=0.001). ConclusionAltered 3D aortic hemodynamics are impacted by the morphology of congenitally malformed aortic valves.J. Magn. Reson. Imaging 2014;40:1342-1346. (c) 2013 Wiley Periodicals, Inc.
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