期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 36, 期 5, 页码 1113-1123出版社
WILEY-BLACKWELL
DOI: 10.1002/jmri.23748
关键词
MR spectroscopic imaging; breast spectral quantification; spectral modeling; echo-planar spectroscopic imaging; prelocalization
资金
- NIH [NCI 1RC1EB010617-01, NIH P41 RR08079, R01 CA120509, NCI R01 CA123194]
- DoD [BC093217]
- UNM Cancer Center
Purpose: To quantitatively measure tCho levels in healthy breasts using Proton-Echo-Planar-Spectroscopic-Imaging (PEPSI). Materials and Methods: The two-dimensional mapping of tCho at 3 Tesla across an entire breast slice using PEPSI and a hybrid spectral quantification method based on LCModel fitting and integration of tCho using the fitted spectrum were developed. This method was validated in 19 healthy females and compared with single voxel spectroscopy (SVS) and with PRESS prelocalized conventional Magnetic Resonance Spectroscopic Imaging (MRSI) using identical voxel size (8 cc) and similar scan times (similar to 7 min). Results: A tCho peak with a signal to noise ratio larger than 2 was detected in 10 subjects using both PEPSI and SVS. The average tCho concentration in these subjects was 0.45 +/- 0.2 mmol/kg using PEPSI and 0.48 +/- 0.3 mmol/kg using SVS. Comparable results were obtained in two subjects using conventional MRSI. High lipid content in the spectra of nine tCho negative subjects was associated with spectral line broadening of more than 26 Hz, which made tCho detection impossible. Conventional MRSI with PRESS prelocalization in glandular tissue in two of these subjects yielded tCho concentrations comparable to PEPSI. Conclusion: The detection sensitivity of PEPSI is comparable to SVS and conventional PRESS-MRSI. PEPSI can be potentially used in the evaluation of tCho in breast cancer. A tCho threshold concentration value of similar to 0.7 mmol/kg might be used to differentiate between cancerous and healthy (or benign) breast tissues based on this work and previous studies. J. Magn. Reson. Imaging 2012;36:11131123. (c) 2012 Wiley Periodicals, Inc.
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