期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 37, 期 4, 页码 950-957出版社
WILEY-BLACKWELL
DOI: 10.1002/jmri.23878
关键词
high-intensity focused ultrasound; tissue thermal conductivity; high temperature; magnetic resonance-guided high intensity focused ultrasound
资金
- Ronald MacDonald Fund at St. Luke's Episcopal Hospital
- Texas Center for Superconductivity at the University of Houston
- Philips Healthcare
Purpose: To estimate the local thermal conductivity of porcine thigh muscle at temperatures required for magnetic resonance imaging (MRI)-guided high-intensity focused ultrasound (MRgHIFU) surgery (6090 degrees C). Materials and Methods: Using MRgHIFU, we performed 40 volumetric ablations in the thigh muscles of four pigs. Thirty-five of the sonications were successful. We used MRI to monitor the resulting temperature increase. We then determined local thermal conductivity by analyzing the spatiotemporal spread of temperature during the cooling period. Results: The thermal conductivity of MRgHIFU-treated porcine thigh muscle fell within a narrow range (0.52 +/- 0.05 W/[m*K]), which is within the range reported for porcine thigh muscle at temperatures of <40 degrees C (0.52 to 0.62 W/[m*K]). Thus, there was little change in the thermal conductivity of porcine thigh muscle at temperatures required for MRgHIFU surgery compared to lower temperatures. Conclusion: Our MRgHIFU-based approach allowed us to estimate, with good reproducibility, the local thermal conductivity of in vivo deep tissue in real time at temperatures of 60 degrees C to 90 degrees C. Therefore, our method provides a valuable tool for quantifying the influence of thermal conductivity on temperature distribution in tissues and for optimizing thermal dose delivery during thermal ablation with clinical MRgHIFU. J. Magn. Reson. Imaging 2013;37:950957. (c) 2012 Wiley Periodicals, Inc.
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