期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 35, 期 2, 页码 449-455出版社
WILEY
DOI: 10.1002/jmri.22839
关键词
dark blood MRA; atherosclerosis; carotid stenosis; MR angiography
资金
- NHLBI NIH HHS [R01 HL095563] Funding Source: Medline
Purpose: To evaluate the use of a T2-weighted SPACE sequence (T2w-SPACE) to assess carotid stenosis via several methods and compare its performance with contrast-enhanced magnetic resonance angiography (ceMRA). Materials and Methods: Fifteen patients with carotid atherosclerosis underwent dark blood (DB)-MRI using a 3D turbo spin echo with variable flip angles sequence (T2w-SPACE) and ceMRA. Images were coregistered and evaluated by two observers. Comparisons were made for luminal diameter, luminal area, degree of luminal stenosis (NAS-CET: North American Symptomatic Endarterectomy Trial; ECST: European Carotid Surgery Trial, and area stenosis), and vessel wall area. Degree of NASCET stenosis was clinically classified as mild (<50%), moderate (50%-69%), or severe (>69%). Results: Excellent agreement was seen between ceMRA and T2w-SPACE and between observers for assessment of lumen diameter, lumen area, vessel wall area, and degree of NASCET stenosis (r > 0.80, P < 0.001). ECST stenosis was consistently higher than NASCET stenosis (48 +/- 14% vs. 24 +/- 22%, P < 0.001). Area stenosis (72 +/- 2%) was significantly higher (P < 0.001) than both ESCT and NASCET stenosis. Conclusion: DB-MRI of carotid arteries using T2w-SPACE is clinically feasible. It provides accurate measurements of lumen size and degree of stenosis in comparison with ceMRA and offers a more reproducible measure of ECST stenosis than ceMRA.
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