期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 31, 期 3, 页码 531-537出版社
WILEY
DOI: 10.1002/jmri.22070
关键词
diffusion-weighted magnetic resonance imaging; apparent diffusion coefficient; distributed diffusion coefficient; stretched-exponential; brain tumor; glioma
资金
- National Institutes of Health
- National Cancer Institute [PO1CA85878, PO1CA59827, 1PO1CA87634, R24CA83099, P50CA93990]
Purpose: To compare apparent diffusion coefficients (ADCs) with distributed diffusion coefficients (DDCs) in high-grade gliomas. Materials and Methods: Twenty patients with high-grade gliomas prospectively underwent diffusion-weighted MRI. Traditional ADC maps were created using b-values of 0 and 1000 s/mm(2). In addition, DDC maps were created by applying the stretched-exponential model using b-values of 0, 1000, 2000, and 4000 s/mm(2). Whole-tumor ADCs and DDCs (in 10(-3) mm(2)/s) were measured and analyzed with a paired t-test, Pearson's correlation coefficient, and the Bland-Altman method. Results: Tumor ADCs (1.14 +/- 0.26) were significantly lower (P = 0.0001) than DDCs (1.64 +/- 0.71). Tumor ADCs and DDCs were strongly correlated (R = 0.9716: P < 0.0001), but mean bias +/- limits of agreement between tumor ADCs and DDCs was -0.50 +/- 0.90. There was a clear trend toward greater discordance between ADC and DDC at high ADC values. Conclusion: Under the assumption that the stretched-exponential model provides a more accurate estimate of the average diffusion rate than the mono-exponential model, our results suggest that for a little diffusion attenuation the mono-exponential fit works rather well for quantifying diffusion in high-grade gliomas, whereas it works less well for a greater degree of diffusion attenuation.
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