期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 30, 期 2, 页码 277-285出版社
WILEY
DOI: 10.1002/jmri.21825
关键词
experimental allergic encephalomyelitis (EAE); diffusion imaging (DTI); acute axonal injury; axial diffusivity (AD)
To evaluate the ability of diffusion tensor imaging (DTI) to detect and monitor acute axonal injury in swine spinal cord with acute experimental allergic encephalomy elitis (EAE). Materials and Methods: Magnetic resonance imaging of the cervical spinal cord was performed in vivo at different time points through the onset and progession of EAE using a 3 Tesla clinical scanner. The DTI parameters were calculated in four separate regions of interest at the C2/C3 level. The quatitative DTI-pathology and DTI-clinical correlations were verified. Results: In the monophasic acute course of EAE onset and progression axial diffusivity (AD) decrease correlates with acute axonal injury (r = -0.84; P < 0.001). By contrast, radial diffusivity does not change and no demyelination in histopathology was detected. Moreover, a clear correlation between clinical disease and axial diffusivity was found in two swine EAE models (r = -0.86; P < 0.001 and r = -0.92; P < 0.001). Conclusion: AD corresponds with axonal injury in the absence of demyelination and may-be-a useful noninvasive tool to investigate the underlying pathogenic processes of multiple sclerosis and to monitor the effects of experimental treatments for axonal injury.
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