期刊
JOURNAL OF MAGNETIC RESONANCE
卷 244, 期 -, 页码 114-124出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2014.02.023
关键词
Chemical exchange; CPMG experiments; Carver Richards equation; Two-site exchange
资金
- BBSRC
- BBSRC [BB/J014346/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/J014346/1] Funding Source: researchfish
The Carr-Purcell-Meiboom-Gill (CPMG) experiment is widely used to quantitatively analyse the effects of chemical exchange on NMR spectra. In a CPMG experiment, the effective transverse relaxation rate, R-2,R-eff, is typically measured as a function of the pulse frequency, nu(CPMG). Here, an exact expression for how R-2,(eff) varies with nu(CMPG) is derived for the commonly encountered scenario of two-site chemical exchange of in-phase magnetisation. This result, summarised in Appendix A, generalises a frequently used equation derived by Carver and Richards, published in 1972. The expression enables more rapid analysis of CPMG data by both speeding up calculation of R-2,R-eff over numerical methods by a factor of ca. 130, and yields exact derivatives for use in data analysis. Moreover, the derivation provides insight into the physical principles behind the experiment. (C) 2014 The Author. Published by Elsevier Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据